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Investigators have found that Mara promotes testosterone secretion not only by increasing cAMP levels via upregulation of luteinizing hormone receptor expression in Leydig cell (Xiong and Zhou, 1994; Chen et al., 2014), but also by upregulating the mRNA expression of key enzymes involved in the conversion of cholesterol to testosterone, such as StAR, Cyp17a1, and PBR (Chen et al., 2014).